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Not like most benzodiazepines, methaqualone acts like a negative allosteric modulator more info at a number of GABA-A receptor subtypes, which has a tendency to cause an excitatory response in neurons expressing Individuals receptors. Because methaqualone may be either excitatory or inhibitory depending upon the subunit composition from the GABA-A receptor, it could be characterised as being a blended GABA-A receptor modulator.[six] The methaqualone binding web-site is distinct within the benzodiazepine, barbiturate, and neurosteroid binding internet sites over the GABA-A receptor intricate, and it could partly overlap With all the etomidate binding web-site.[six]
Professional manufacture of methaqualone was halted due to prevalent abuse and addictiveness. It's really a member in the quinazolinone course. Buy quaalude online
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